Safflowercanslightlyexcitetheheart,reducecoronaryresistance,increasecoronaryflowandmyocardialnutrientbloodflow.Highdoseofsafflowerdecoctioncaninhibittheisolatedtoadheart,butlowdoseofsafflowerdecoctioncanslightlyexcitetheheart,5g/kgintravenousinjectioncanslightlyexcitetheheartofdogsinsitu.Safflowerinjectioncanobviouslyslowdowntheheartrateofisolatedrabbitheart.Alargedoseofsafflowerextractcanmakeisolatedtoadandratheartstopindiastolicphase.However,washingoffthedrugsolutioncanquicklyrestoretheheartrate,andtheamplitudeandfrequencyaresignificantlyincreasedComparedwithpotassiumcitrateandothercardiacarrestdrugs,safflowerextracthastheadvantagesofrapidrecoveryofnormalheartbeatwithoutfibrillation,Safflowerwaterextractcanincreasecoronaryflowinanesthetizeddogs.Safflowerinjection10mg/kgintravenouslycanincreasecoronaryflowby60.4%ineutopicdogs.Safflowercanalsoslightlyincreasemyocardialnutritionalbloodflowinmice红花有轻度兴奋心脏、降低冠脉阻力、增加冠脉流量和心肌营养性血流量的作用．大剂量红花煎剂对离体蟾蜍心脏有抑制作用，小剂量对心脏却有轻微的兴奋作用，使心跳有力．煎剂0.5g/kg静脉注射可轻度兴奋在位犬心．红花注射液对离体兔心有较明显的减慢心率作用．大剂量的红花浸剂能使离体蟾蜍与大鼠心脏停止于舒张期．但洗去药液可迅速恢复心跳，幅度与频率有明显增加．动物实验证明：与乙酰胆碱、枸橼酸钾等心脏停跳药物相比较，红花浸剂有使心脏迅速恢复正常跳动而不易发生纤颤的优点．红花水浸液有一定的扩张冠状动脉作用，但维持时间较短．红花水提取液小剂量可增加麻醉狗冠脉流量．红花注射液10mg/kg静脉注射能使在位犬心冠脉流量增加60.4%．红花亦能轻度增加小鼠心肌营养性血流量．Safflowercanimprovetheimbalanceofoxygensupplyanddemandinischemicmyocardium.Animalexperimentsshowthatsafflowercanreducethedegreeofmyocardialischemia,reducethescopeofinfarctionafteracutecoronaryocclusion,andslowdowntheheartrate,Thisbeneficialeffectmayberelatedtothereductionofmyocardialoxygenconsumption.SafflowerdecoctionhasobviousprotectiveeffectonmyocardialischemiainducedbyPituitrininratsorrabbits;Saffloweryellowcanimprovemicrocirculationandantagonizearrhythmiainducedbyaconitine.However,ithasbeenreportedthatsafflowerwaterextractcanslightlyincreasemyocardialoxygenconsumptioninanesthetizeddogs红花对实验性心肌缺血、心肌梗死或心律失常等动物模型均有不同程度的对抗作用．红花能改善缺血心肌氧的供求失调．动物实验表明：红花能使麻醉犬的心肌缺血程度减轻，急性冠脉闭塞后的梗死范围缩小，心率减慢，尤其对梗死的“边缘区”有明显的保护作用，可以挽救梗死边缘区濒危缺血心肌，并使心电图ST段抬高的幅度显著下降，这种有益作用可能与其降低心肌耗氧量有关．红花煎剂给大鼠或家兔腹腔注射，对垂体后叶素引起的心肌缺血有明显的保护作用；但给大鼠口服红花煎剂连续4天则无对抗作用．红花*色素有改善微循环，对抗乌头碱引起的心律失常等作用．但亦有报告指出，红花水提取液则使麻醉犬心肌耗氧量稍有增加。F！*手医妃王爷休书请拿好免费阅读·谢瑶楚寒小说免费·*手医妃王爷休书请拿好全文阅读·*手医妃王爷休书请拿好txt在线完结·*手医妃王爷休书请拿好完整版大结局
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